ABSTRACT
Objective To investigate the relationship between platelet-to-lymphocyte ratio(PLR) and the prognosis of diabetes ketoacidosis (DKA).Methods 120 patients with DKA were divided into two groups:the DKA survived group (n=86) and the DKA died group (n=34).80 patients with type 2 diabetes (T2DM)were also enrolled in our study as the control group.Their clinical and biochemical parameters were determined.PLR was calculated by blood routine examination.Results Patients in the DKA died group had higher PLR than patients in the DKA survived group and the control group.According to logistic regression analysis,age [OR=2.119(95％CI 1.506-3.994),P=0.032],infection [OR=2.047(95％ CI 1.421-3.885),P=0.021],Glasgow coma score [OR=0.523(95％ CI 0.394-0.693),P=O.O11],simultaneous other organ dysfunction [OR=3.642 (95％ CI 2.287-5.442),P=0.006],PLR[OR=3.073 (95％ CI 1.951-5.142),P＜0.001],mechanical ventilation [OR=3.846 (95％ CI 2.623-5.113),P＜0.001] and lactic acid [0R=2.854 (95％ CI 1.514-4.216,P=0.008] were all significantly correlated with the prognosis of DKA.The optimal cutoff value of PLR for predicting the prognosis of DKA was 192.26.Its sensitivity and specificity were 82.40％ and 67.60％,respectively.Conclusion PLR can be used as a sensitive indicator to predict the prognosis of DKA.